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![]() ![]() Overall, the OCB-positive patients had greater brain atrophy than the negatives, particularly in white matter areas ( p = 0.029).įrom there, the team looked at regions of the brain, using three different multivariate orthogonal projections to latent structures (OPLS) statistical models. The researchers performed MRI scans on 28 OCB-negative and 35 OCB-positive patients with either relapsing-remitting MS or secondary progressive MS and matched them for disease activity. Theirs, they say, is the first study to look at global CNS differences between these two subsets. ![]() According to the authors of the new study, most MRI studies of OCB-positive and -negative patients have focused only on the differences between brain lesions. Though not every person with MS has OCBs, their presence is generally associated with a younger age of onset and a poorer disease outcome. The presence of OCBs in the CSF has often been used as a diagnostic criterion in MS. Oligoclonal bands are immunoglobulins that collect in a patient’s blood plasma or cerebrospinal fluid (CSF). The authors argue that OCB-negative patients should be considered a distinct subgroup of MS patients ( Ferreira et al., 2014). Patients lacking oligoclonal bands (OCBs) have less overall brain atrophy than those who test positive for the bands, according to a new study published in the Journal of Neuroimmunology. ![]()
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